(DOWNLOAD) "Microdialysis in Drug Development" by Markus Müller " Book PDF Kindle ePub Free
eBook details
- Title: Microdialysis in Drug Development
- Author : Markus Müller
- Release Date : January 13, 2012
- Genre: Medical,Books,Professional & Technical,
- Pages : * pages
- Size : 3538 KB
Description
In vivo target site concentrations are probably the most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical reach. Today, a direct measurement of target site concentrations is possible by employing microdialysis or complementary approaches such as imaging technologies. Microdialysis, initially conceived in the 1970ies, has become a standard tool in drug development. This comprehensive overview of current microdialysis technology covers general and disease-specific aspects of microdialysis by international experts in the field. It provides useful information for colleagues in academia and industry who are interested PK-PD aspects of drug development.